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Important General Information
The peak respiratory depressant effect of methadone occurs later. So, persists longer than its peak pharmacologic effect.
A high degree of opioid tolerance does not end the possibility of methadone overdose. So, we have reports during conversion to methadone from chronic. High-dose treatment with other opioid agonists. And so, during initiation of methadone treatment of addiction. in subjects before abusing high doses.
There is high interpatient variability in absorption, metabolism, and relative analgesic potency.
With repeated dosing, methadone stored in the liver and then released. prolonging the duration of potential toxicity.
Steady-state plasma concentrations are not attained. until 3 to 5 days after initiation of dosing.
METHADOSE has a narrow therapeutic index, especially when combined with other drugs.
The major hazards of methadone are respiratory depression. And, also to a lesser degree, systemic hypotension. So, Respiratory arrest, shock, cardiac arrest, and death have occurred. 40mg methadone tablets availabe for sale. Methadone 40 mg Prescription Pain Relievers
The most observed adverse reactions includes lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. So, these effects seem to be more prominent in ambulatory patients. In such individuals, lower doses are advisable. Methadone 40 mg Prescription Pain Relievers.
Other adverse reactions include the following: (listed under each subsection)
- Body as a Whole – asthenia (weakness), edema, headache
- Digestive – abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, glossitis
- Metabolic and Nutritional – hypokalemia, hypomagnesemia, weight gain
- Nervous – agitation, confusion, disorientation, dysphoria, euphoria, insomnia, seizures
- Respiratory – pulmonary edema, respiratory depression
- Skin and Appendages – pruritus, urticaria, other skin rashes, and rarely, hemorrhagic urticaria
- Special Senses – hallucinations, visual disturbances
- Urogenital – amenorrhea, antidiuretic effect, reduced libido and/or potency, urinary retention or hesitancy
- Androgen deficiency – Cases of androgen deficiency have occurred with chronic use of opioids.
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